You're looking for a portable version of AutoCAD 2010 64-bit in English. Here's what I found:
: Windows 7 (Ultimate, Professional, Home Premium), Windows Vista (SP1), or Windows XP Professional x64 Edition (SP2 or later). autocad 2010 portable 64 bits ingles full
AutoCAD 2010 was released when 64-bit was still new. Many "portable" repacks fail to map the correct memory addresses, leading to the dreaded "Fatal Error: Unhandled Access Violation" message. You're looking for a portable version of AutoCAD
It introduced the .dwg 2010 file format, which remained the standard for several subsequent releases. Understanding the "Portable" Version 64-bit Compatibility Issues
Completely free, open-source, and truly portable via PortableApps.com platform. The downside: It does not support 3D, and the DWG compatibility is imperfect (uses libdxfrw).
AutoCAD 2010 Portable 64-bit English Full Version: Is It Worth the Risk?