The writers' strike of 2007–2008 significantly impacted this season, reducing the episode count. The setting moves to Sona, a gritty Panamanian prison run by the inmates rather than the guards. Michael must break out a mysterious prisoner known as Whistler.
– Michael needs to recover the blueprint from his memory. The Key – Michael needs Sara’s infirmary key. Tonight – Bellick discovers the hole. Go – The inmates finally make their move. Flight – The "Fox River Eight" are on the run. 🏃 Season 2: On the Run (2006–2007)
– Michael finds the chemical agent needed for the walls.
24 (22 regular + 2 movie parts) Core Plot: Michael, Lincoln, and Sara team with self-serving FBI agent Don Self to take down The Company from the inside. They must steal six key data cards (Scylla) that contain the conspiracy’s heart.