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Pain as a Driver: Sudden aggression or reactivity is frequently caused by undiagnosed pain (e.g., arthritis, dental disease, or otitis). An animal in pain may lash out to protect itself, often mislabeled by owners as "meanness."
Endocrine Disorders: Conditions like hypothyroidism in dogs or hyperthyroidism in cats can cause aggression, anxiety, or lethargy.
Neurological Issues: Brain tumors, seizure disorders, or cognitive dysfunction syndrome (dementia in senior pets) can manifest as sudden behavioral changes.

Frontiers in Veterinary Science | Animal Behavior and Welfare zooskool simone first cut free

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